Yes Nathan Drake is a murderer, he has killed hundreds of people during his adventures whether he was in the right to do that is another question.
Many people focus on Nathan Drake despite there is a countless amount of video game characters and protagonists such as Agent47, Assassin’s Creeds many protagonists, Samus Aran, and Lara Croft is a good example as she is also a treasure hunter like Nathan Drake. Many video game fans, however, are angry with this as Nathan Drake is always portrayed as a righteous character who always does good compared to other characters such as the ones mentioned above address their killings usually by expressing some kind of remorse or saying how they wish they didn’t have to do this. However, Drake is made to look like a role model good guy despite at the end of the day he is looking for the treasures partly for monetary gain at least if that is not the full reason.
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Furthermore, people point out that a lot of other characters have a much better reason, for example, Ratchet from Ratchet & Clank is there to save the world from quintillion aliens and Ezio from the Assassin’s Creed series is trying to stop the Templars from taking over the world and Commander Shepard from the Mass Effect trilogy is trying to save everyone in the entire universe.